何欢简介

何欢，男，1993年生人，武汉大学物理化学博士，一流学科特聘教授，硕士生导师，主要从事新型靶向抗肿瘤药物分子的理性设计、合成和早期成药性评价研究。以第一作者或通讯作者在Journal of Medicinal Chemistry (6篇)，European Journal of Medicinal Chemistry，Bioorganic Chemistry，Journal of Organic Chemistry等期刊发表SCI论文18篇（含中科院分区一区论文10篇，ESI高被引论文1篇），主持国家自然科学基金2项，省自然科学基金1项。

邮箱：ivy@whu.edu.cn

2010年9月-2014年6月，武汉大学，化学基地班，学士；

    2014年9月-2019年6月，武汉大学，物理化学，博士(硕博连读)。导师：刘义教授。

【主持项目】

1. 国家自然科学基金（8230132305）：超声激活的靶向SOS1降解剂的设计、合成及其抗胰腺癌活性研究，2024/1-2026/12，30万；

2. 国家自然科学基金（2236030055）：雌激素受体靶向光敏降解剂的设计、合成及其作用机制，2024/1-2027/12，32万；

3. 省自然科学基金（2023AFB048）：靶向组蛋白去乙酰化酶6光敏降解剂的设计、合成及其作用机制，2024/1-2025/12，5万；

4. 我校自然科学专项（特岗）科研基金项目，60万。

【近期发表论文】

  1.He H. ; Wang Z. W.; Peng X. K.: Qing L. L.; Zhang Y.; Fu S. J.; Xu J.; Li Y. Y.*; Zhang S.L.*. Identification of a sonically activated degrader of methionine adenosyltransferase 2A by an in silico approach assisted with the hole−electron analysis. J. Med. Chem. 2024, 67,543-554. (IF = 7.3)

  2.Xu J.; Zhao A.; Chen D.; Wang J.; Ma J.; Qing L. L.; Li Y. Y.; Fang H. X.; He H. *; Pan W. D.*; Zhang S. L.* Discovery of tricyclic PARP7 inhibitors with high potency, selectivity, and oral bioavailability. Eur. J. Med. Chem. 2024, 266, 116160. (IF = 6.7)

  3.Li Y. Y.; Sun M.; Chen X.; Zhang S. L.*; He H. *. Design of sonosensitizers integrated with resveratrol motif for synergetic sonodynamic therapy and NF-κB transcription suppression of breast cancer. J. Med. Chem. 2023, 66, 6149-6159. (IF = 7.3)

  4.Zhang S. L.; Qing L. L.; Wang Z. W.; Zhang Y.; Li Y. Y.; Fang H. X.*; Liu Y.; He H. *. Design and structural optimization of methionine adenosyltransferase 2A (MAT2A) inhibitors with high in-vivo potency and oral bioavailability. J. Med. Chem. 2023, 66, 4849-4867. (IF = 7.3) 

  5.Zhang S. L.; Zhang Y.; Wang Z. W.; Qing L. L.; Fu S. J..; Xu J.; Li Y. Y. *; Fang H. X.*; He H. *. Exploring the structural-activity relationship of hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]oxazine derivatives as potent and orally-bioavailable PARP7 inhibitors. Eur. J. Med. Chem. 2023, 261, 115836. (IF = 6.7)

  6.He H.; Chen R. Q.; Wang Z. W.; Qing L. L.; Zhang Y.; Liu Y.; Pan W. D.*; Fang H. X.*; Zhang S. L.*. Design of orally-bioavailable tetra-cyclic phthalazine SOS1 inhibitors with high selectivity against EGFR. Bioorg. Chem. 2023, 136, 106536. (IF = 5.1) 

  7.Luo X. T.; Liu J. W.; Sun C.; Zhang F.; Yu W. Q.; Jiang B. B.; Li C.; Chen X. Q. *; He H. *; Xu Z. Q *. Red-emissive carbon dots combined with ferric ions for detection of total antioxidant capacity in food. ACS Appl. Nano Mater. 2023, 6, 14332. (IF = 5.9)

  8.Zhang S. L. *; Li Y. Y.; Li T.; Zhang Y.; Li H. M.; Cheng Z. Z.; Peng N.; Liu Y.; Xu J. *; He H. * Activable targeted protein degradation platform based on light-triggered singlet oxygen. J. Med. Chem. 2022, 65, 3632-3643.  (IF = 7.3) 

  9.Zhang S.L.; Zhang Y.; Chen X.; Xu J.; Fang H. X.; Li Y. Y. *; Liu Y.*; He H.*. Design and structural optimization of orally-bioavailable SOS1 inhibitors for the treatment of KRAS-driven carcinoma. J. Med. Chem. 2022, 65, 23, 15856-15877. (IF = 7.3)

  10.He H.; Zhang Y.; Xu J.; Li Y. Y.; Fang H. X. *; Liu Y. *; Zhang S.L.*. Discovery of orally-bioavailable SOS1 inhibitors for suppressing KRAS-driven carcinoma. J. Med. Chem. 2022, 65, 19, 13158-13171 (IF = 7.3)

  11.Zhang, Y.; Ding, X.; Xie, F.; Gao, M. J.; Qiu, J. L.; Wang, Z. W.; Qing, L. L.; Yan, J. Q.; Li, Y. Y.; Xu, J.; Jiao, Y. H.;Liu, Y.*; He H. *; Zhang, S. L.* Targeted recruitment and degradation of estrogen receptor α by photothermal polydopamine nanoparticles for breast tumor ablation. Adv. Healthc. Mater. 2022, 11, 2200960. (IF = 11.0)

  12.Li T.; Zhang Y.; Wang Z. W.; Qing L. L.; Zhang L. J. Peng N.; Liu Y. *; Zhang S. L. *; He H. * AIEgen based turn-on fluorescent probes of histone deacetylase 6 via restriction of molecular motion. Sensor Actuat. B-Chem. 2022, 364, 131882. (IF = 9.2)

  13.Xu H., Lou X., Xie J., Qin Z., He H. *, Gao X. * Regioselective approach to β‑peroxyl alcohols and ethers from alkenes. J. Org. Chem. 2022, 87, 9957-9968. (IF=4.1)

  14.Xu, J.; Feng, Y.; Han, L.; Yi, M.; Jiao, Y. H.; Zhang, S. L.*; He H.* Photoexcited graphene oxides activate silent viruses in bacteria in dependency on their sizes. Environ. Sci. Nano. 2022, 9, 3918-3926 (IF = 9.4)

  15.He H., Xu J., Li C., Gao T., Jiang P. *, Jiang F. L., Liu Y. * Insights into mechanism of A beta(42) fibril growth on surface of graphene oxides: oxidative degree matters. Adv. Healthc. Mater. 2021, 10, 2100436 (IF=11.0)