赵春深简介

赵春深，男，1978年2月，沈阳药科大学博士学位。我校教授，16877太阳集团制药工程药研室主任，硕士研究生导师，主要从事医药中间体及新药研发工作。

邮箱：390214939@qq.com

1996年9月1日-2000年7月1日  沈阳药科大学   学士学位

2000年9月1日-2003年7月1日  沈阳药科大学   硕士学位

2003年9月1日-2006年7月1日  沈阳药科大学   博士学位

2007年4月1日-2008年3月31日     日本京都药科大学      博士后

2006年9月-2018年12月      我校      副教授

2013年               被贵阳市科技局聘为“贵州市科技特派员”

2015年               被贵州省科技厅聘为“贵州省科技特派员”

2018年12月-至今          我校       教授

【主持项目】

1.   系列医药中间体的开发       横向主持2018.01-2021.01

2.   吡啶类合成砌块的研发       贵州省科技厅基金  主持      2013-05 至2015-06

3.   基于吡啶并咪唑联氨传感材料合成及性能研究贵州省科技厅参与．2015-01 至2017-12

4.   蛋白酪氨酸激酶抑制剂的合成研究，产学研项目  2012-09-01至 2017-09-31

5.   阿比朵尔衍生物的合成研究，产学研项目  主持  2012-09-01至 2017-09-31

【近期发表论文】

1.  Hong Sun, Liyuan Deng,  Weiyin  Hu,  Tianhui  Liao,  Weike  Liao,  Huifang  Chai,  Chunshen Zhao*. Synthesis, crystal structure, vibrational properties and DFT studies of 4-(furan-2-ylmethyl)-1-(thiomorpholinomethyl)-[1,2,4]triazolo[4,3-a]quinazon-5(4H)-one.Journal of Molecular Structure. 2022, DOI: 10.1016/j.molstruc.2021.131395.

2. Weiyin Hu, Liyuan Deng, Hong Sun, Zhixu Zhou, Huifang Chai*, Chunshen Zhao*. Synthesis,     crystal    structure       and DFT              study     of           a     new       compound 4-(2-chlorobenzyl)-1-(5-fluoro-2-hydroxy-3-(thiomorpholinomethyl)phenyl-[1,2,4] triazolo[4,3-a]quinazolin-5(4H)-one.           Journal   of    Heterocyclic Chemistry,    2021,     DIO: 10.1002/jhet.4333.

3.  Peng-Yue Huang, Zhi-Song Yang, Qing-Mei Wu, De-Zheng Yang, Jun-Jiang Chen, Hui-Fang Chai, Chun-Shen Zhao. Synthesis, crystal structure and DFT study of compound methyl 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate   and (2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(pyrrolidin-1-yl)methanone.Journal of Structural Chemistry, 2021, 62(6): 845-852.

4.  Zhi-Song Yang, Peng-Yue Huang, Jun-Jiang Chen, Yu-Mei Chen, Ting Gao, Hui-Fang Chai, Chun-Shen Zhao*. Synthesis, crystal structure and DFT study of 1-(2-bromobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Journal of Structural Chemistry, 2021, 62(6): 928-937.

5.  Ye Liu, Hao Deng, Qian Ren, Zhixu Zhou, Chunshen Zhao*, Huifang Chai*. Synthesi, characterization of a new compound 4-(2-chlorobenzyl)imidazo[1,2-a]quinazolin-5 (4H)-one and      DFT      study      of      crystal      structure,      MEP      and      HOMO–LUMO. Journal of Structural Chemistry, 2021, 62(8): 1372-1379.

6.  Qian Ren, Peng-Yue Huang Ye Liu, Wei-Ke Liao, Zhi-Xu Zhou*, Chun-Shen Zhao*. Synthesis, crystal structure and DFT study of a novel compound 4-(2-chlorobenzyl)-1- (5-nitro-2-(pyrrolidin-1-yl)phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one. Journal of Structural Chemistry, 2021, 62(9): 1571-1581.

7.  Minggang Teng, Zhixu Zhou, Yumei Qin, Yongli Zhao, Chunshen Zhao*, Jianxin Cao*. A water-soluble fluorescence sensor with high specificity for detecting hydrazine in river water detection and A549 cell imaging. Sensors & Actuators: B. Chemical, 2020, 311: 127914.

8.  Qiuyan Zhang, Zhuyan Huang, Yi Le, Xue Zou, Zhixu Zhou, Chunshen Zhao*. Synthesis, crystal structure and DFT study of 6-hydroxybentazon. Chinese Journal of Structural Chemistry. 2020, 39(2): 269-278.

9.  Ye Liu, Yongli Zhao, Qian Ren, Zhixu Zhou, Huifang Chai, Chunshen Zhao*. Synthesis, crystal structure and DFT study of a novel planar bipyridyl compound 6,6’-bis(trifluoromethyl)-3,3’-bipyridine. Journal of Molecular Structure. 2020, 1208: 127869.

10. Zhang Dan; Han Jie; Lu Wenchao; Lian Fulin; Wang Jun; Lu Tian; Tao Hongru; Xiao Senhao; Zhang Fengcai; Liu Yu-Chih; Liu Rongfeng; Zhang Naixia; Jiang Hualiang; Chen Kaixian; Zhao Chunshen*; Luo Cheng*. Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening. Bioorganic Chemistry, 2019, 86: 494-500.

11. Peng Zhao, Zhu-yan Huang, Chunshen Zhao*, Sheng Liu*. Facile Formation of Eight-membered Rings of Indoloazocine Framework via Intramolecular Oxidative Heck Cyclization. J. Heterocyclic Chem., 2019, 56, 108-113.

12. Yumei Qin, Dan Long Xiong Zhu, Zhixu Zhou, Huifang Chai*, Chunshen Zhao*. Synthesis, crystal structure and DFT study of a new compound 6-(2-fluorophenyl)-N-(p-tolyl)imidazo[1,2-a]pyridine-2-carboxamide, Journal of Structural Chemistry, 2019, 60(12):1917-1924.

13. Chunshen Zhao*, Fei Li, Shuo Yang, Li Liu, Zhuyan Huang, Huifang Chai*. Chemoselective iodination of 6-substituted imidazo[1,2-a]pyridine. Chemistry of Heterocyclic Compounds, 2018, 54(5): 568–571.